High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses

High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses

Abstract Objectives We aimed to gain an understanding of the paradox of the immunity in COVID‐19 patients with T cells showing both functional defects and hyperactivation and enhanced proliferation. Methods A total of 280 hospitalised patients with COVID‐19 were evaluated for cytokine profiles and c...

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Bibliographic Details
Main Authors: Min Xie, Joseph Yunis, Yin Yao, Jing Shi, Yang Yang, Pengcheng Zhou, Kaili Liang, Yanmin Wan, Ahmed Mehdi, Zhian Chen, Naiqi Wang, Shuyun Xu, Min Zhou, Muqing Yu, Ke Wang, Yu Tao, Ying Zhou, Xiaochen Li, Xiansheng Liu, Xiao Yu, Yunbo Wei, Zheng Liu, Jonathan Sprent, Di Yu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
CD25+PD‐1+ CD8+ T cell
COVID‐19 patients
disease severity
SARS‐CoV‐2
soluble CD25
Online Access:https://doi.org/10.1002/cti2.1251

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