Treg Therapies Revisited: Tolerance Beyond Deletion

by Nina Pilat, Jonathan Sprent, Jonathan Sprent
Published 2021-01-01

Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells

by Juhee Kim, Juhee Kim, Jun Young Lee, Jun Young Lee, Kyungjin Cho, Kyungjin Cho, Sung-Wook Hong, Sung-Wook Hong, Kwang Soon Kim, Kwang Soon Kim, Jonathan Sprent, Jonathan Sprent, Sin-Hyeog Im, Sin-Hyeog Im, Charles D. Surh, Charles D. Surh, Jae-Ho Cho, Jae-Ho Cho
Published 2018-08-01

TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

by Jun-Young Lee, Eunjin Lee, Sung-Wook Hong, Daeun Kim, O. Eunju, Jonathan Sprent, Sin-Hyeog Im, You Jeong Lee, Charles D. Surh
Published 2020-01-01

Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells

by Jun Young Lee, Jun Young Lee, Juhee Kim, Juhee Kim, Jaeu Yi, Jaeu Yi, Daeun Kim, Daeun Kim, Hee-Ok Kim, Hee-Ok Kim, Daehee Han, Daehee Han, Jonathan Sprent, Jonathan Sprent, You Jeong Lee, You Jeong Lee, Charles D. Surh, Charles D. Surh, Charles D. Surh, Jae-Ho Cho, Jae-Ho Cho
Published 2018-03-01

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

by Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, Jennifer Jackson, Peter Schofield, Elissa K. Deenick, Cecile King, Tri Giang Phan, Kylie E. Webster, Jonathan Sprent, Daniel Christ
Published 2017-05-01

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes

by Claudia Loetsch, Joanna Warren, Adrienne Laskowski, Rodrigo Vazquez-Lombardi, Christoph Jandl, David B. Langley, Daniel Christ, David R. Thorburn, David K. Ryugo, Jonathan Sprent, Marcel Batten, Cecile King
Published 2017-11-01

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

by Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
Published 2017-03-01

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells

by Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King, Jonathan Sprent
Published 2016-11-01

High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses

by Min Xie, Joseph Yunis, Yin Yao, Jing Shi, Yang Yang, Pengcheng Zhou, Kaili Liang, Yanmin Wan, Ahmed Mehdi, Zhian Chen, Naiqi Wang, Shuyun Xu, Min Zhou, Muqing Yu, Ke Wang, Yu Tao, Ying Zhou, Xiaochen Li, Xiansheng Liu, Xiao Yu, Yunbo Wei, Zheng Liu, Jonathan Sprent, Di Yu
Published 2021-01-01