Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

Abstract Background Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by endothelial cells, basal lamina, and peri...

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Bibliographic Details
Main Authors: Marina S. Hernandes, Bernard Lassègue, Lula L. Hilenski, Jonathan Adams, Ning Gao, Chia-Yi Kuan, Yu-Yo Sun, Lihong Cheng, Daniel S. Kikuchi, Manuel Yepes, Kathy K. Griendling
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Poldip2
Cerebral ischemia
Blood-brain barrier
Cytokines
Astrocytes
Online Access:http://link.springer.com/article/10.1186/s12974-017-1032-1

Internet

http://link.springer.com/article/10.1186/s12974-017-1032-1

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