Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

Genome-wide association studies for non-syndromic orofacial clefting (OFC) have identified single nucleotide polymorphisms (SNPs) at loci where the presumed risk-relevant gene is expressed in oral periderm. The functional subsets of such SNPs are difficult to predict because the sequence underpinnin...

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Bibliographic Details
Main Authors: Huan Liu, Kaylia Duncan, Annika Helverson, Priyanka Kumari, Camille Mumm, Yao Xiao, Jenna Colavincenzo Carlson, Fabrice Darbellay, Axel Visel, Elizabeth Leslie, Patrick Breheny, Albert J Erives, Robert A Cornell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
periderm
orofacial cleft
enhancers
machine learning
Online Access:https://elifesciences.org/articles/51325

Internet

https://elifesciences.org/articles/51325

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