Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects Protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors

Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects Protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors

Methamphetamine (MA) is a toxic, addictive drug shown to modulate learning and memory, yet the neural mechanisms are not fully understood. We investigated the effects of 2 weekly injections of MA (30 mg/kg) on working memory using the radial 8-arm maze (RAM) across 5 weeks in adolescent-age mice. M...

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Bibliographic Details
Main Authors: Stephen H Braren, Damian eDrapala, Ingrid K Tulloch, Peter A Serrano
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Hippocampus
Methamphetamine
glutamate receptors
working memory
d1
excitotoxicity
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00438/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00438/full

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