A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism

A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism

BackgroundThe diagnosis of congenital hyperinsulinism (CHI) may be hampered by a plasma (p-) insulin detection limit of 12–18 pmol/L (2–3 mU/L).ObjectiveTo evaluate the diagnostic performance of a sensitive insulin immunoassay and to find the optimal p-insulin cut-off for the diagnosis of CHI.Method...

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Bibliographic Details
Main Authors: Julie Siersbæk, Annette Rønholt Larsen, Mads Nybo, Henrik Thybo Christesen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
hypoglycemia
congenital hyperinsulinism
children
diagnostic performance
immunoassays
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.614993/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.614993/full

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