Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]
DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription, recombination, and chromosome segregation. Stud...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2019-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-1704/v1 |