One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions
An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction...
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PeerJ Inc.
2018-06-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/5065.pdf |
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doaj-54a9f3fac6d04f10b470877349b74f292020-11-24T23:13:10ZengPeerJ Inc.PeerJ2167-83592018-06-016e506510.7717/peerj.5065One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditionsGiovanna Bosica0Ramon Zammit1Department of Chemistry, University of Malta, Msida, MaltaDepartment of Chemistry, University of Malta, Msida, MaltaAn environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss.https://peerj.com/articles/5065.pdfHeterogeneous catalystNitro-MannichSolvent-freeMulticomponentOne-pot |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Giovanna Bosica Ramon Zammit |
| spellingShingle |
Giovanna Bosica Ramon Zammit One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions PeerJ Heterogeneous catalyst Nitro-Mannich Solvent-free Multicomponent One-pot |
| author_facet |
Giovanna Bosica Ramon Zammit |
| author_sort |
Giovanna Bosica |
| title |
One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| title_short |
One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| title_full |
One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| title_fullStr |
One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| title_full_unstemmed |
One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| title_sort |
one-pot multicomponent nitro-mannich reaction using a heterogeneous catalyst under solvent-free conditions |
| publisher |
PeerJ Inc. |
| series |
PeerJ |
| issn |
2167-8359 |
| publishDate |
2018-06-01 |
| description |
An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss. |
| topic |
Heterogeneous catalyst Nitro-Mannich Solvent-free Multicomponent One-pot |
| url |
https://peerj.com/articles/5065.pdf |
| work_keys_str_mv |
AT giovannabosica onepotmulticomponentnitromannichreactionusingaheterogeneouscatalystundersolventfreeconditions AT ramonzammit onepotmulticomponentnitromannichreactionusingaheterogeneouscatalystundersolventfreeconditions |
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1725599023563276288 |