Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses

Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses

Background: Pancreatic patient–derived organoids (PDOs) are a well-established model for studying pancreatic ductal adenocarcinoma (PDAC) carcinogenesis and are potential predictors of clinical responses to chemotherapy. Oncolytic virotherapy is envisioned as a novel treatment modality for pancreati...

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Bibliographic Details
Main Authors: Giulia Raimondi, Ana Mato-Berciano, Silvia Pascual-Sabater, Maria Rovira-Rigau, Miriam Cuatrecasas, Constantino Fondevila, Santiago Sánchez-Cabús, Harry Begthel, Sylvia F. Boj, Hans Clevers, Cristina Fillat
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:EBioMedicine
Subjects:
Pancreatic ductal adenocarcinoma (PDAC)
Patient-derived organoids (PDO)
Oncolytic adenovirus (OA)
Orthotopic tumours
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301614

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http://www.sciencedirect.com/science/article/pii/S2352396420301614

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