Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that connect these oncogenic pathways, thus promoting tu...

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Bibliographic Details
Main Authors: Marco Napoli, Xiaobo Li, Hayley D. Ackerman, Avani A. Deshpande, Ivan Barannikov, Marlese A. Pisegna, Isabelle Bedrosian, Jürgen Mitsch, Philip Quinlan, Alastair Thompson, Kimal Rajapakshe, Cristian Coarfa, Preethi H. Gunaratne, Douglas C. Marchion, Anthony M. Magliocco, Kenneth Y. Tsai, Elsa R. Flores
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18973-w

Internet

https://doi.org/10.1038/s41467-020-18973-w

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