Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination

Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and axonal loss. Demyelinating lesions are associated with infiltrating T lymphocytes, bone marrow-derived macrophages (BMDM), and activated resident microglia. Tissue damage...

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Bibliographic Details
Main Authors: Carine Savarin, Ranjan Dutta, Cornelia C. Bergmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
macrophages
microglia
central nervous system
demyelination
viral encephalomyelitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01325/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01325/full

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