Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI

Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI

Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis, and myocardial infarction, and die prematurely. We examined effects of apoE and SR-BI deficiency on macrophage cholesterol homeostas...

Full description

Bibliographic Details
Main Authors: Patricia G. Yancey, Jerome W. Gray, Yu Hong, Evelyn E. Griffin, Brian E. Cox, Vladimir R. Babaev, Fazio Sergio, MacRae F. Linton
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein E
cholesterol efflux
lysosomal lipid engorgement
HDL
cholesterol trafficking
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435606

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520435606

Similar Items