Tracing Antibody Repertoire Evolution by Systems Phylogeny

Tracing Antibody Repertoire Evolution by Systems Phylogeny

Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the maj...

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Bibliographic Details
Main Authors: Alexander Dimitri Yermanos, Andreas Kevin Dounas, Tanja Stadler, Annette Oxenius, Sai T. Reddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
systems immunology
phylogenetics
antibody lineage
B cell evolution
Ig-Seq
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02149/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02149/full

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