Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells

Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells

Abstract Background Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated in progression of tumours, including gliomas. The aim...

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Bibliographic Details
Main Authors: Juan de los Santos-Jiménez, José A. Campos-Sandoval, Clara Márquez-Torres, Nieves Urbano-Polo, David Brøndegaard, Mercedes Martín-Rufián, Carolina Lobo, Ana Peñalver, María C. Gómez-García, Janet Martín-Campos, Carolina Cardona, Laura Castilla, Felipe da Costa Souza, Tzuling Cheng, Juan A. Segura, Francisco J. Alonso, Rui Curi, Alison Colquhoun, Ralph J. DeBerardinis, Javier Márquez, José M. Matés
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Biomedical Science
Subjects:
Antioxidant enzymes
Cancer
Glioblastoma
Glutaminase
microRNA
Oxidative stress
Online Access:https://doi.org/10.1186/s12929-021-00712-y

Internet

https://doi.org/10.1186/s12929-021-00712-y

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