USP13 mediates PTEN to ameliorate osteoarthritis by restraining oxidative stress, apoptosis and inflammation via AKT-dependent manner

Osteoarthritis is a chronic, systemic and inflammatory disease. However, the pathogenesis and understanding of RA are still limited. Ubiquitin-specific protease 13 (USP13) belongs to the deubiquitinating enzyme (DUB) superfamily, and has been implicated in various cellular events. Nevertheless, its...

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Bibliographic Details
Main Authors: Jianming Huang, Zhiyang Ye, Jun Wang, Qichuan Chen, Danlei Huang, Haoyuan Liu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312828