A correlation analysis to assess event-free survival as a trial-level surrogate for overall survival in early breast cancer

Background: Event-free survival (EFS) has been listed on the FDA Table of Surrogate Endpoints as a surrogate measure that can be considered for accelerated or traditional approval in breast cancer. However, no studies have evaluated the correlation between the treatment effects on EFS and treatment...

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Bibliographic Details
Main Authors: Bishal Gyawali, Elvira D'Andrea, Jessica M. Franklin, Aaron S. Kesselheim
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:EClinicalMedicine
Subjects:
FDA
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537021000109