The EBV-Encoded Oncoprotein, LMP1, Recruits and Transforms Fibroblasts via an ERK-MAPK-Dependent Mechanism

The EBV-Encoded Oncoprotein, LMP1, Recruits and Transforms Fibroblasts via an ERK-MAPK-Dependent Mechanism

Latent membrane protein 1 (LMP1), the major oncoprotein encoded by Epstein–Barr virus (EBV), is expressed at widely variable levels in undifferentiated nasopharyngeal carcinoma (NPC) biopsies, fueling intense debate in the field as to the importance of this oncogenic protein in disease pathogenesis....

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Bibliographic Details
Main Authors: Alexandra M Davis, Abigail Rapley, Christopher W Dawson, Lawrence S Young, Mhairi A Morris
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pathogens
Subjects:
LMP1
EBV
NPC
fibroblast
myofibroblast
cancer-associated fibroblasts
Online Access:https://www.mdpi.com/2076-0817/10/8/982

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