Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation

Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct mechanism by which EV71 induces apoptosis and autophagy in neur...

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Bibliographic Details
Main Authors: Lei You, Junbo Chen, Weiyong Liu, Qi Xiang, Zhen Luo, Wenbiao Wang, Wei Xu, Kailang Wu, Qi Zhang, Yingle Liu, Jianguo Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Virulence
Subjects:
hand foot and mouth disease (hfmd)
enterovirus 71 (ev71)
neurological pathogenesis
peroxisome
acyl-coa oxidase 1 (acox1)
reactive oxygen species (ros)
Online Access:http://dx.doi.org/10.1080/21505594.2020.1766790

Internet

http://dx.doi.org/10.1080/21505594.2020.1766790

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