Drimane-type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-resistant Human Breast Cancer Cell Line

Drimane-type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-resistant Human Breast Cancer Cell Line

Multidrug resistance (MDR) is the main cause of failure in the chemotherapy of cancer patients. The present study aimed to evaluate the effects of sesquiterpene coumarins of Ferula gummosa fruits on P-glycoprotein (P-gp)–mediated MDR. Drimane-type sesquiterpene coumarins from the fruits of F. gummos...

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Bibliographic Details
Main Authors: Mehrdad Iranshahi, Chantal Barthomeuf, Mathilde Bayet-Robert, Philippe Chollet, Davood Davoodi, Sonia Piacente, Ramin Rezaee, Amirhossein Sahebkar
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
Breast cancer
Ferula gummosa
P-glycoprotein inhibitor
Sesquiterpene coumarins
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411016302152

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http://www.sciencedirect.com/science/article/pii/S2225411016302152

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