Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice.

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice.

BACKGROUND: Endothelin-1 participates in the pathophysiology of heart failure. The reasons for the lack of beneficial effect of endothelin antagonists in heart failure patients remain however speculative. The anti-apoptotic properties of ET-1 on cardiomyocytes could be a reasonable explanation. We t...

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Bibliographic Details
Main Authors: Susi Heiden, Nicolas Vignon-Zellweger, Shigeru Masuda, Keiko Yagi, Kazuhiko Nakayama, Masashi Yanagisawa, Noriaki Emoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3921186?pdf=render

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http://europepmc.org/articles/PMC3921186?pdf=render

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