Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer

Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer

The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAFV600E and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite instability, which have an excellent clinical outcome....

Full description

Bibliographic Details
Main Authors: Alexandra M. Kane, Lochlan J. Fennell, Cheng Liu, Jennifer Borowsky, Diane M. McKeone, Catherine E. Bond, Stephen Kazakoff, Ann-Marie Patch, Lambros T. Koufariotis, John Pearson, Nicola Waddell, Barbara A. Leggett, Vicki L.J. Whitehall
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861930418X

Internet

http://www.sciencedirect.com/science/article/pii/S147655861930418X

Similar Items