The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation

The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation

Glucose levels inside solid tumors are low as compared with normal surrounding tissue, forcing tumor cells to reprogram their metabolism to adapt to such low glucose conditions. Unlike normal tissue, tumor cells experience glucose starvation, making the targeting of pathways supporting survival duri...

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Bibliographic Details
Main Authors: Ran Marciano, Hila Ben David, Barak Akabayov, Barak Rotblat
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
medicinal chemistry
cancer metabolism
amuvatinib
mechanistic target of rapamycin (mtor)
synthetic lethality
Online Access:https://www.mdpi.com/1422-0067/21/3/1041

Internet

https://www.mdpi.com/1422-0067/21/3/1041

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