Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells

Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells

Abstract Background Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation of extracellular matrix. Severe LF causes cirrhosis and even liver failure, a major cause of morbidity and mortality worldwide. Transplantation o...

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Bibliographic Details
Main Authors: Yunqi Yao, Zhemin Xia, Fuyi Cheng, Qingyuan Jang, Jiao He, Cheng Pan, Lin Zhang, Yixin Ye, Yuan Wang, Shuang Chen, Dongsheng Su, Xiaolan Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Caveolin-1
hPMSCs
HSCs
Liver fibrosis
TGF-β/Smad pathway
Online Access:https://doi.org/10.1186/s13287-021-02358-x

Internet

https://doi.org/10.1186/s13287-021-02358-x

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