Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study

Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study

Abstract Background The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults. Methods This was a multinational, single-dose, open-label, phase I study to describe the pharmacod...

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Bibliographic Details
Main Authors: Dagmar Kubitza, Stefan Willmann, Michael Becka, Kirstin Thelen, Guy Young, Leonardo R. Brandão, Paul Monagle, Christoph Male, Anthony Chan, Gili Kennet, Ida Martinelli, Paola Saracco, Anthonie W. A. Lensing
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Thrombosis Journal
Subjects:
Developmental hemostasis
Pharmacodynamics
Pharmacokinetics
Rivaroxaban
Venous thromboembolism
Online Access:http://link.springer.com/article/10.1186/s12959-018-0186-0

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http://link.springer.com/article/10.1186/s12959-018-0186-0

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