Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming ensures survival is unclear. Employing comprehensive metabolom...

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Bibliographic Details
Main Authors: Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S Parks, Cristina Furdui, Peter W Stacpoole, Jennifer Martinez, Charles E McCall, Matthew A Quinn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
sepsis
liver
inflammation
metabolism
steatosis
Online Access:https://elifesciences.org/articles/64611

Internet

https://elifesciences.org/articles/64611

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