Carotenoid-Enriched Fractions From Spondias mombin Demonstrate HER2 ATP Kinase Domain Inhibition: Computational and In Vivo Animal Model of Breast Carcinoma Studies

Carotenoid-Enriched Fractions From Spondias mombin Demonstrate HER2 ATP Kinase Domain Inhibition: Computational and In Vivo Animal Model of Breast Carcinoma Studies

Human epidermal growth factor 2 (HER2) is overexpressed in about 20% of breast cancer and is associated with a poor prognosis. We report in this study that carotenoid-enriched fractions from Spondias mombin demonstrate HER2 ATP kinase domain inhibition. HER2 breast carcinoma was modeled in female Wi...

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Bibliographic Details
Main Authors: Damilohun Samuel Metibemu, Oluseyi Adeboye Akinloye, Idowu Olaposi Omotuyi, Jude Ogechukwu Okoye, Mustapha Ayodele Popoola, Adio Jamiu Akamo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
human epidermal growth factor 2
liquid chromatography/mass spectrometry
7,12-dimethylbenz[a]anthracene (DMBA)
breast cancer
carotenoids
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.687190/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.687190/full

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