Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

The inwardly rectifying K+ channel Kir4.1 is broadly expressed by CNS glia and deficits in Kir4.1 lead to seizures and myelin vacuolization. However, the role of oligodendrocyte Kir4.1 channels in controlling myelination and K+ clearance in white matter has not been defined. Here, we show that selec...

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Bibliographic Details
Main Authors: Valerie A Larson, Yevgeniya Mironova, Kimberly G Vanderpool, Ari Waisman, John E Rash, Amit Agarwal, Dwight E Bergles
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
Kir4.1
myelin
seizure
potassium
oligodendrocyte
epilepsy
Online Access:https://elifesciences.org/articles/34829

Internet

https://elifesciences.org/articles/34829

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