Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway

Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway

Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity in the kidney can be a surrogate marker for renal failure or renal fibrosis. Fatty acid oxidation provides energy to renal tubular cells. Ca<sup>2+</sup> is requi...

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Bibliographic Details
Main Authors: Yen-Chung Lin, Mai-Szu Wu, Yuh-Feng Lin, Chang-Rong Chen, Chang-Yu Chen, Chang-Jui Chen, Che-Chou Shen, Kuan-Chou Chen, Chiung-Chi Peng
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
nifedipine
renal lipotoxicity
AMPK
calcium channel blockers
lipin-1
sterol regulatory element-binding proteins 1/2 (SREBP1/2)
Online Access:https://www.mdpi.com/1422-0067/20/7/1570

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https://www.mdpi.com/1422-0067/20/7/1570

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