Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose phosphate pathway gene RPIA and that targeting...
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Bibliographic Details
| Main Authors: |
Naiara Santana-Codina,
Anjali A. Roeth,
Yi Zhang,
Annan Yang,
Oksana Mashadova,
John M. Asara,
Xiaoxu Wang,
Roderick T. Bronson,
Costas A. Lyssiotis,
Haoqiang Ying,
Alec C. Kimmelman |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07472-8
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