Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

Asparagine and Glutamine Side-Chains and Ladders in HET-s(218–289) Amyloid Fibrils Studied by Fast Magic-Angle Spinning NMR

Asparagine and glutamine side-chains can form hydrogen-bonded ladders which contribute significantly to the stability of amyloid fibrils. We show, using the example of HET-s(218–289) fibrils, that the primary amide side-chain proton resonances can be detected in cross-polarization based solid-state...

Full description

Bibliographic Details
Main Authors: Thomas Wiegand, Alexander A. Malär, Riccardo Cadalbert, Matthias Ernst, Anja Böckmann, Beat H. Meier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
solid-state NMR
fast MAS
amyloid fibrils
hydrogen bond
asparagine ladder
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.582033/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.582033/full

Similar Items