Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts

Mitochondrial Dysfunction and Alterations in Mitochondrial Permeability Transition Pore (mPTP) Contribute to Apoptosis Resistance in Idiopathic Pulmonary Fibrosis Fibroblasts

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by increased activation of fibroblasts/myofibroblasts. Previous reports have shown that IPF fibroblasts are resistant to apoptosis, but the mechanisms remain unclear. Since inhibition of the mitochondrial permeability transit...

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Bibliographic Details
Main Authors: Erika Rubí Luis-García, Carina Becerril, Alfonso Salgado-Aguayo, Omar Emiliano Aparicio-Trejo, Yair Romero, Edgar Flores-Soto, Criselda Mendoza-Milla, Martha Montaño, Victoria Chagoya, José Pedraza-Chaverri, Mohammed El Hafidi, Marisol Orozco-Ibarra, Annie Pardo, Moisés Selman
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
electron transport chain
IPF
mitochondrial dysfunction
mitochondrial networks
myofibroblasts
Online Access:https://www.mdpi.com/1422-0067/22/15/7870

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https://www.mdpi.com/1422-0067/22/15/7870

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