Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord

Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord

The postnatal rodent spinal cord in-vitro is a useful model to investigate early pathophysiological changes after injury. While low dose nicotine (1 µM) induces neuroprotection, how higher doses affect spinal networks is unknown. Using spinal preparations of postnatal wild-type Wistar rat and Wnt1Cr...

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Bibliographic Details
Main Authors: Jaspreet Kaur, Graciela L. Mazzone, Jorge B. Aquino, Andrea Nistri
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
nicotine toxicity
Wnt1 pathway
spinal cord injury
locomotor networks
excitotoxicity
fictive locomotion
Online Access:https://www.mdpi.com/1422-0067/22/17/9572

Internet

https://www.mdpi.com/1422-0067/22/17/9572

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