Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours

Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours

The lysyl oxidase (LOX) family of enzymes are a major driver in the biogenesis of desmoplastic matrix at the primary tumour and secondary metastatic sites. With the increasing interest in and development of anti-stromal therapies aimed at improving clinical outcomes of cancer patients, the Lox famil...

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Bibliographic Details
Main Authors: Yordanos F.I. Setargew, Kaitlin Wyllie, Rhiannon D. Grant, Jessica L. Chitty, Thomas R. Cox
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
lysyl oxidases
extracellular matrix
cancer
tumour microenvironment
tumorigenesis
anti-stromal targeting
Online Access:https://www.mdpi.com/2072-6694/13/3/491

Internet

https://www.mdpi.com/2072-6694/13/3/491

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