Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1.

The atherosclerotic process begins when vascular endothelial cells undergo pro-inflammatory changes such as aberrant activation to dysfunctional phenotypes and apoptosis, leading to loss of vascular integrity. Our laboratory has demonstrated that exposure of mice to second hand smoke triggers an inc...

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Bibliographic Details
Main Authors: Jon M Florence, Agnieszka Krupa, Laela M Booshehri, Timothy C Allen, Anna K Kurdowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5293219?pdf=render