Investigating ADR mechanisms with Explainable AI: a feasibility study with knowledge graph mining

Investigating ADR mechanisms with Explainable AI: a feasibility study with knowledge graph mining

Abstract Background Adverse drug reactions (ADRs) are statistically characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. This is true even for hepatic or skin toxicities, which are classically monitored duri...

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Bibliographic Details
Main Authors: Emmanuel Bresso, Pierre Monnin, Cédric Bousquet, François-Elie Calvier, Ndeye-Coumba Ndiaye, Nadine Petitpain, Malika Smaïl-Tabbone, Adrien Coulet
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Medical Informatics and Decision Making
Subjects:
Adverse drug reaction
Molecular mechanism
Mechanism of action
Explanation
Data mining
Machine learning
Online Access:https://doi.org/10.1186/s12911-021-01518-6

Internet

https://doi.org/10.1186/s12911-021-01518-6

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