Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells

Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells

Previous work has shown that reduced expression of PLCXD3, a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin secretion with an unclear mechanism. In the current study, we aim to investigate the mechanism underlying this effect using human islets and rat INS-1...

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Bibliographic Details
Main Authors: Hayat Aljaibeji, Debasmita Mukhopadhyay, Abdul Khader Mohammed, Sarah Dhaiban, Mahmood Y. Hachim, Noha M. Elemam, Nabil Sulaiman, Albert Salehi, Jalal Taneera
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
type 2 diabetes
microarray
gene expression
RNA sequencing
PLCXD3
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00735/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00735/full

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