Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

Neurofibromatosis type 1 (NF1) is a monogenic syndrome that gives rise to numerous symptoms including cognitive impairment, skeletal abnormalities, and growth of benign nerve sheath tumors. Nearly all NF1 patients develop cutaneous neurofibromas (cNFs), which occur on the skin surface, whereas 40&am...

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Bibliographic Details
Main Authors: Jineta Banerjee, Robert J Allaway, Jaclyn N Taroni, Aaron Baker, Xiaochun Zhang, Chang In Moon, Christine A Pratilas, Jaishri O Blakeley, Justin Guinney, Angela Hirbe, Casey S Greene, Sara JC Gosline
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Genes
Subjects:
neurofibromatosis type 1
nerve sheath tumor
cancer
latent variables
machine learning
supervised learning
transfer learning
random forest
metaviper
tumor deconvolution
Online Access:https://www.mdpi.com/2073-4425/11/2/226

Internet

https://www.mdpi.com/2073-4425/11/2/226

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