Effective DNA/RNA co-extraction for analysis of microRNAs, mRNAs, and genomic DNA from formalin-fixed paraffin-embedded specimens.

Effective DNA/RNA co-extraction for analysis of microRNAs, mRNAs, and genomic DNA from formalin-fixed paraffin-embedded specimens.

BACKGROUND: Retrospective studies of archived human specimens, with known clinical follow-up, are used to identify predictive and prognostic molecular markers of disease. Due to biochemical differences, however, formalin-fixed paraffin-embedded (FFPE) DNA and RNA have generally been extracted separa...

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Bibliographic Details
Main Authors: Adam Kotorashvili, Andrew Ramnauth, Christina Liu, Juan Lin, Kenny Ye, Ryung Kim, Rachel Hazan, Thomas Rohan, Susan Fineberg, Olivier Loudig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3326040?pdf=render

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http://europepmc.org/articles/PMC3326040?pdf=render

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