Impact of <i>CYP3A5</i>, <i>POR,</i> and <i>CYP2C19</i> Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation

Impact of <i>CYP3A5</i>, <i>POR,</i> and <i>CYP2C19</i> Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation

Single nucleotide polymorphisms in drug-metabolizing genes may affect tacrolimus pharmacokinetics. Here, we investigated the influence of genotypes of <i>CYP3A5</i>, <i>CYP2C19</i>, and <i>POR</i> on the concentration/dose (C/D) ratio of tacrolimus and episodes of...

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Bibliographic Details
Main Authors: Kimitaka Suetsugu, Yasuo Mori, Nanae Yamamoto, Tomohiro Shigematsu, Toshihiro Miyamoto, Nobuaki Egashira, Koichi Akashi, Satohiro Masuda
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>CYP3A5</i>
<i>POR</i>
<i>CYP2C19</i>
single nucleotide polymorphism
tacrolimus
hematopoietic stem cell transplantation
Online Access:https://www.mdpi.com/1422-0067/20/10/2413

Internet

https://www.mdpi.com/1422-0067/20/10/2413

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