Urinary Extracellular Vesicle Protein Profiling and Endogenous Lithium Clearance Support Excessive Renal Sodium Wasting and Water Reabsorption in Thiazide-Induced Hyponatremia

Urinary Extracellular Vesicle Protein Profiling and Endogenous Lithium Clearance Support Excessive Renal Sodium Wasting and Water Reabsorption in Thiazide-Induced Hyponatremia

Introduction: Thiazide diuretics are among the most widely used antihypertensive medications worldwide. Thiazide-induced hyponatremia (TIH) is 1 of their most clinically significant adverse effects. A priori TIH must result from excessive saliuresis and/or water reabsorption. We hypothesized that pa...

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Bibliographic Details
Main Authors: Sarath K. Channavajjhala, Roger Bramley, Theresa Peltz, Wilna Oosthuyzen, Wenjing Jia, Sue Kinnear, Barry Sampson, Nick Martin, Ian P. Hall, Matthew A. Bailey, James W. Dear, Mark Glover
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Kidney International Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024918302110

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http://www.sciencedirect.com/science/article/pii/S2468024918302110

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