Pharmacological Aspects of the Effects of Tramadol on G-Protein Coupled Receptors

Tramadol is an analgesic that is used worldwide, but its mechanisms of action have not been elucidated. It has been speculated that tramadol acts primarily through the activation of µ-opioid receptors and the inhibition of monoamine reuptake. The majority of studies to date have focused on ion chann...

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Bibliographic Details
Main Authors: Kouichiro Minami, Yasuhito Uezono, Yoichi Ueta
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319343026