Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells. The transcription factor forkhead box p3 (Foxp3) play...

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Bibliographic Details
Main Authors: Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg
Format: Article
Language:English
Published: Taylor & Francis Group 2019-07-01
Series:OncoImmunology
Subjects:
immunosuppression
tregs
foxp3
tcrm mab
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1570778

Internet

http://dx.doi.org/10.1080/2162402X.2019.1570778

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