Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and en...

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Bibliographic Details
Main Authors: Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt, Philip S. Low
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10565-7

Internet

https://doi.org/10.1038/s41467-019-10565-7

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