Novel transgenic mice for inducible gene overexpression in pancreatic cells define glucocorticoid receptor-mediated regulations of beta cells.

Novel transgenic mice for inducible gene overexpression in pancreatic cells define glucocorticoid receptor-mediated regulations of beta cells.

Conditional gene deletion in specific cell populations has helped the understanding of pancreas development. Using this approach, we have shown that deleting the glucocorticoid receptor (GR) gene in pancreatic precursor cells leads to a doubled beta-cell mass. Here, we provide genetic tools that per...

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Bibliographic Details
Main Authors: Bertrand Blondeau, Iman Sahly, Emmanuelle Massouridès, Amrit Singh-Estivalet, Bérengère Valtat, Delphine Dorchene, Frédéric Jaisser, Bernadette Bréant, Francois Tronche
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281827?pdf=render

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http://europepmc.org/articles/PMC3281827?pdf=render

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