Secondary structures involving the poly(A) tail and other 3’ sequences are major determinants of mRNA isoform stability in yeast

Secondary structures involving the poly(A) tail and other 3’ sequences are major determinants of mRNA isoform stability in yeast

In Saccharomyces cerevisiae, previous measurements of mRNA stabilities have been determined on a per-gene basis. We and others have recently shown that yeast genes give rise to a highly heterogeneous population of mRNAs due to extensive alternative 3’ end formation. Typical genes can have fifty or m...

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Bibliographic Details
Main Authors: Zarmik Moqtaderi, Joseph V. Geisberg, Kevin Struh
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-04-01
Series:Microbial Cell
Subjects:
mRNA isoforms
mRNA stability
polyU element
poly(A) tail
mRNA structure
Saccharomyces cerevisiae
Online Access:http://microbialcell.com/researcharticles/secondary-structures-involving-the-polya-tail-and-other-3-sequences-are-major-determinants-of-mrna-isoform-stability-in-yeast/

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http://microbialcell.com/researcharticles/secondary-structures-involving-the-polya-tail-and-other-3-sequences-are-major-determinants-of-mrna-isoform-stability-in-yeast/

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