The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major cell type responsible for wound healing, rema...

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Bibliographic Details
Main Authors: Miho Takahashi, Yoshie Umehara, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, François Niyonsaba
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
angiogenesis
human β-defensin
fibroblast
migration
proliferation
wound healing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712781/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.712781/full

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