Development of a NS2B/NS3 protease inhibition assay using AlphaScreen® beads for screening of anti-dengue activities

Background: Dengue infection is an endemic infectious disease and it can lead to dengue fever, dengue hemorrhagic fever, and/or dengue shock syndromes. Dengue NS2B/NS3 protease complex is essential for viral replication and is a primary target for anti-dengue drug development. In this study, a NS2B/...

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Bibliographic Details
Main Authors: Muhammad Asyraf Abduraman, Maywan Hariono, Rohana Yusof, Noorsaadah Abd Rahman, Habibah A. Wahab, Mei Lan Tan
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018346097