Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and identified 150 ADs. By mRNA display, we showed that 73% of ADs bound the Med15...

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Bibliographic Details
Main Authors: Adrian L Sanborn, Benjamin T Yeh, Jordan T Feigerle, Cynthia V Hao, Raphael JL Townshend, Erez Lieberman Aiden, Ron O Dror, Roger D Kornberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
transcription factor
activation domain
mediator complex
machine learning
high-throughput screening
molecular simulation
Online Access:https://elifesciences.org/articles/68068

Internet

https://elifesciences.org/articles/68068

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