Distilling Robust Design Principles of Biocircuits Using Mixed Integer Dynamic Optimization

A major challenge in model-based design of synthetic biochemical circuits is how to address uncertainty in the parameters. A circuit whose behavior is robust to variations in the parameters will have more chances to behave as predicted when implemented in practice, and also to function reliably in p...

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Bibliographic Details
Main Authors: Irene Otero-Muras, Julio R. Banga
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Processes
Subjects:
Online Access:https://www.mdpi.com/2227-9717/7/2/92