Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy

Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of DNA damage. Cells have evolved with several systems that efficiently repair spontaneous, isolated DNA lesions with a high degree of accuracy. Ionizing radiation and a few radiomimetic chemicals can produce...

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Bibliographic Details
Main Authors: Jac A. Nickoloff, Neelam Sharma, Lynn Taylor
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/11/1/99